The aim of present investigation is to study different process parameters for to development and characterization of metoprolol succinate sustain release tablet prepared by hot melt granulation and compare with marketed tablet. Different process parameters like Effect of Granule Size, Effect of Heating Time, Effect of Melting Temperature, Effect of Hardness. Metoprolol succinate is a beta 1-selective (cardio selective) adrenergic receptor blocking agent also inhibits beta 2-adrenoreceptors, chiefly located in the bronchial and vascular musculature. It is used in the management of hypertension, angina pectoris, cardiac arrhythmias, myocardial infarction, heart failure, and hyperthyroidism and in the prophylactic treatment of migraine. Metoprolol has no sympathomimetic activity. Metoprolol succinate with its incomplete oral bioavailability due to extensive first pass metabolism, short half life 3-4 hrs, and multiple daily dosing, is appropriate for a sustained release formulation. Different formulations of metoprolol are available using polymers and excipients. Hot melt granulation technique is something new technique over previous.
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